Publications

  • For updated list, please visit Google Scholar
  • A list of selected publications arranged topic-wise are given below

    • Cancer research, kinases and PROTACs

  • Rahman S. Z. Saleem, Martin P. Schwalm, Stefan Knapp “Expanding the ligand spaces for E3 ligases for the design of protein degraders” Bioorg Med Chem 2024, 105, 117718 (doi: 10.1016/j.bmc.2024.117718).
  • Sana Iqbal, Farhat Firdous, Muhammad Furqan, Aishah Bilal, Sebastian Öther-Gee Pohl, Nora Julia Doleschall, Kevin B. Myant, Upendra Singh, Abdul-Hamid Emwas, Mariusz Jaremko, Amir Faisal,* Rahman S. Z. Saleem* “Synthesis and Characterization of Bis-amide SSE1917 as a Microtubule-Stabilizing Anticancer Agent” Bioorganic Chem 2024, 143, 107094 (doi: 10.1016/j.bioorg.2023.107094).
  • Farhat Firdous, Sharon Riaz, Muhammad Furqan, Salman Fozail, Khushboo Fatima, Sebastian Öther-Gee Pohl, Nora Julia Doleschall, Kevin B. Myant, Jordan Kahfi, Abdul-Hamid Emwas, Mariusz Jaremko, Ghayoor Abbas Chotana, Rahman S. Z. Saleem,* Amir Faisal* “4-Azapodophyllotoxin Derivatives as Microtubule Targeting Agents that can overcome multidrug resistance: Design, Synthesis, and Biological Evaluation” ASC Med Chem Lett 2023, 14, 10, 1369–1377 (doi: 10.1021/acsmedchemlett.3c00258).
  • Farhat Firdous, Rida Ibrahim, Muhammad Furqan, Hina Khan, Hadeeqa Raza, Upendra Singh, Abdul-Hamid Emwas, Mariusz Jaremko, Ghayoor Abbas Chotana, Amir Faisal*, Rahman S. Z. Saleem* “Synthesis and Characterization of Griseofulvin Derivatives as Microtubule-Stabilizing Agents” ChemistrySelect. 2022, 7, e202202832. (doi: 10.1002/slct.202202832).
  • Muhammad Furqan, Alishba Fayyaz, Farhat Firdous, Hadeeqa Raza, Aishah Bilal, Rahman S. Z. Saleem, Syed Shahzad-ul-Hussan, Daijie Wang, Essam A Ali, Riaz Ullah*, Hidayat Hussain*, Amir Faisal* “Identification and Characterization of Quinones as Aurora Kinase Inhibitors” J. Nat. Prod. 2022, 85, 6, 1503 (doi: 10.1021/acs.jnatprod.1c01222).
  • Usama Bin Farrukh, Aishah Bilal, Huda Zahid, Maheen Iqbal, Safia Manzoor, Farhat Firdous, Muhammad Furqan, Muhammad Azeem, Abdul-Hamid Emwas, Meshari Alazmi, Xin Gao, Rahman S. Z. Saleem*, Amir Faisal* “Synthesis and evaluation of novel carboxamides capable of causing centrosome declustring and apoptosis in breast cancer cells” ChemistrySelect 2022, 7, e202104218 (doi: 10.1002/slct.202104218).
  • Muhammad Usama Tariq, Hira Parveen, Muhammad Furqan, Rahim Ullah, Muhammad Muddassar, Rahman S. Z. Saleem, Vassilios Bavetsias, Spiros Linardopoulos and Amir Faisal* “CCT245718, a Dual FLT3/Aurora A Inhibitor Overcomes D835Y-Mediated Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia Cells.” Br. J. Cancer 2021, 125 (7), 966-974 (doi: 10.1038/s41416-021-01527-2).
    o Selected as best cancer paper in Pakistan and given Bashir-Alavi Award 2022 at 21st Annual Shaukat Khanum Cancer Symposium (SKCS), held in Lahore, Pakistan (Nov 4-6, 2022).
  • Haleema Sadia Malik, Aishah Bilal, Rahim Ullah, Maheen Iqbal, Sardraz Khan, Ishtiaq Ahmed, Karsten Krohn, Rahman S. Z. Saleem, Hidaya Hussain*, Amir Faisal* “Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors” J. Nat. Prod. 2020, 83, 10, 3111 (doi: 10.1021/acs.jnatprod.0c00699).
  • Sharon Riaz, Maheen Iqbal, Rahim Ullah, Rida Zahra, Ghayoor Abbas Chotana, Amir Faisal*, Rahman S.Z. Saleem*. “Synthesis and evaluation of novel α-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance” Bioorg Chem 2019, 87, 123-135 (doi: 10.1016/j.bioorg.2019.03.014).
  • Safia Manzoor, Aishah Bilal, Sardraz Khan, Rahim Ullah, Sunniya Iftikhar, Abdul-Hamid Emwas, Meshari Alazmi, Xin Gao, Ali Jawaid, Rahman S. Z. Saleem*, Amir Faisal* “Identification and characterization of SSE15206, A microtubule depolymerizing agent that overcomes multidrug resistance” Sci. Rep. 2018, 8, 3305 (doi: 10.1038/s41598-018-21642-0).
  • Sunniya Iftikhar, Sardraz Khan, Aishah Bilal, Safia Manzoor, Muhammad Abdullah, Abdel-Hamid Emwas, Salim Sioud, Xin Gao, Ghayoor Abbas Chotana, Amir Faisal*, Rahman S. Z. Saleem* “Synthesis and evaluation of modified chalcone based p53 stabilizing agents” Bioorganic Med. Chem. Lett. 2017, 27, 4101 (doi: 10.1016/j.bmcl.2017.07.042).
  • Thu N.T. Nguyen, Rahman S. Z. Saleem, Micah J. Luderer, Stacy Hovde, R. Willian Henry, Jetze J. Tepe* “Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors” ACS Chem. Biol. 2012, 7, 172 (DOI: 10.1021/cb200320c).
  • Rahman S. Z. Saleem, Theresa A. Lansdell, Jetze J. Tepe* “Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors” Bioorg. Med. Chem. 2012, 20, 1475 (DOI:10.1016/j.bmc.2011.12.054).

    • Fibrillation research

  • Umme Kalsoom, Meshari Alazmi, Syed Usama Bin Farrukh, Nawaf Alshammari, Ghayoor Abbas Chotana, Ibrahim Javed,* Thomas Paul Davis,* Rahman Shah Zaib Saleem* “Structure Dependent Differential Modulation of Aβ Fibrillization by Selenadiazole-Based Inhibitors” ACS Chem Neuroscience 2021, 12 (20) 3806 (doi: 10.1021/acschemneuro.1c00478).
  • Syed Usama Bin Farrukh, Ibrahim Javed, Abdul Qayyum Ather, Abdul-Hamid Emwas, Meshari Alazmi, Xin Gao, Ghayoor Abbas Chotana, Thomas P. Davis, Pu Chun Ke, Rahman S.Z. Saleem* “Synthesis and identification of novel pryidazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation” Bioorg Chem 2019, 84, 339-346 (doi: 10.1016/j.bioorg.2018.11.039).

    • Organoselenium chemistry

  • Rama Alhasan, Guilherme M. Martins, Pedro P. De Castro, Rahman S. Z. Saleem, Ali Zaiter, Isabelle Fries-Raeth, Alexandra Kleinclauss, Caroline Perrin-Sarrado, Eufrânio N. Da Silva Júnior, Patrick Chaimbault, Caroline Gaucher *,Claus Jacob “Selenoneine-derived selenohydantoin with glutathione peroxidase-like activity” Bioorg Med Chem 2023, 94, 117479 (doi: 10.1016/j.bmc.2023.117479).
  • Jana Rendeková, Danuša Vlasáková, Pavel Arsenyan, Jelena Vasiljeva, Muhammad Jawad Nasim, Polina Denezhkin, Wesam Ali, Sandra Huebgen, Karolina Witek, Enrique Domínguez-Álvarez, Ewa Żesławska, Waldemar Tejchman, Rahman S. Z. Saleem, Jadwiga Handzlik, Miroslav Chovanec, and Claus Jacob* “The Selenium-Nitrogen Bond as Basis for Reactive Selenium Species with Pronounced Antimicrobial Activity” Curr. Org. Synth. 2017, 14, 1082. (doi: 10.2174/1570179414666170525104735).

    • Photophysical profiling

  • Humera Baig, Rimsha Irfan, Alvina Rasool, Syed Zajif Hussain, Sabir Ali Siddique, Javed Iqbal, Meshari Alazmi, Alshammari Nawaf, Amira Alazmi, Amer AlGhadhban, Abdel Moneim E. Sulieman, Kamaleldin B. Said, Habib-ur-Rehman, Rahman S. Z. Saleem* “Synthesis, Photophysical, Voltammetric, and DFT Studies of 4-Aminochalones” J Photochem Photobiol A: Chemistry, 2023, 114790 (doi: 10.1016/j.jphotochem.2023.114790).
  • Humera Baig, Alvina Rasool, Syed Zajif Hussain, Javed Iqbal, Raja Shahid Ashraf, Ghayoor Abbas Chotana, Habib-ur-Rehman, Rahman S. Z. Saleem* “Synthesis, Photophysical, Electrochemical and Computational Studies of Novel 2-aminoimidazolones” J Photochem Photobiol A: Chemistry 2022, 429 113918 (doi: 10.1016/j.jphotochem.2022.113918).

    • Methodology

  • Rahman S. Z. Saleem and Jetze J. Tepe* “Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones” J. Org. Chem. 2010, 75, 4330-2 (DOI: 10.1021/jo100716m).
    o The article was highlighted in Synfacts 2010, 0997.
  • Aansa Hanif, Aniqa Sardar, Meshari Alazmi, Haniya Tariq, Abdul-Hamid Emwas, Xin Gao, Ghayoor A Chotana, Rahman S.Z. Saleem*,” A Novel One-Pot Three-Component Reaction for Rapid Access of Arylidene 2-aminoimidazolone Derivatives” ChemistrySelect 2019, 4, 1753-1756 (doi: 10.1002/slct.201803409).

    • Natural product chemistry

  • Samina Mehnaz, Rahman S. Z. Saleem, Basit Yameen, Isabelle Pianet, Gregor Schnakenburg, Halina Pietraszkiewicz, Fred Valeriote, Michaele Josten, Hans-Georg Sahl, Scott G. Franzblau, Harald Gross* “Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain Pseudomonas aurantiaca PB-St2” J. Nat. Prod. 2013, 76 (2), 135 (DOI: 10.1021/np3005166).
  • Izzah Shahid, Muhammad Rizwan, Deeba Noreen Baig, Rahman S. Z. Saleem, Kauser Abdullah Malik and Samina Mehnaz* “Secondary metabolites production and plant growth promotion by Pseudomonas chlororaphis and P. aurantiaca strains isolated from cactus, cotton and para grass”, J. Microbiol. Biotechnol. 2017, 27 (3), 480 (doi: 10.4014/jmb.1601.01021).
  • Rahman S. Z. Saleem and Jetze J. Tepe* “A Concise Total Synthesis of Hymenialdisine” Tet. Lett. 2015, 56, 3011 (DOI:10.1016/j.tetlet.2014.10.022).

    • Reviews

  • Kainat Ahmed, M. Iqbal Choudhary, Rahman S. Z. Saleem* “Heterocyclic Pyrimidine Derivatives as Promising Antibacterial Agents” Eu J Med Chem 2023, 115701 (doi: 10.1016/j.ejmech.2023.115701).
  • Kainat Ahmed, Ghayoor Abbas Chotana, Amir Faisal, Rahman S. Z. Saleem* “Chemical Synthesis of Selenium-containing Peptides” Mini-Reviews in Medicinal Chemistry 2023, 23 (10), 1090 (doi: 10.2174/1389557522666220826140910).
  • Syed Muhammad Umer, Mehwish Solangi, Khalid Mohammed Khan *, Rahman S. Z. Saleem* “Indole-Containing Natural Products 2019-2022: Isolations, Reappraisals, Syntheses, and Biological Activities” Molecules, 2022, 27(21), 7586 (doi: 10.3390/molecules27217586).
  • Kainat Ahmed, Delawar Ashraf, Ghayoor Abbas Chotana, Amir Faisal, Khalid M. Khan*, Rahman S. Z. Saleem* “Selenium-containing Peptides and their Biological Applications” Curr Med Chem 2022, 29(42) 6379 (doi: 10.2174/0929867329666220214104010).
  • Sharon Riaz, Khalid Mohammed Khan, Ghayoor Abbas Chotana, Amir Faisal, Rahman Shah Zaib Saleem* “Recent advances in the chemistry and biology of the antimitotic Podophyllotoxin and its derivatives” Current Nutraceuticals 2022, 3, e021121197553 (doi: 10.2174/2665978602666211102103152).
  • Rimsha Irfan, Shikufa Mousavi, Meshari Alazmi, Rahman S. Z. Saleem* “A Comprehensive Review of Aminochalcones” Molecules 2020, 25(22), 5381(doi: 10.3390/molecules25225381).